منابع مشابه
HTRA 2 ( HtrA serine peptidase 2 )
Note Amplification of 2p13-16 has frequently been found in non-Hodgkin's lymphoma, mediastinal thymic B-cell lymphoma and in some cases of neuroblastoma, ovarian cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer and synovial sarcoma (Knuutila et al., 1998). Translocations and deletions of region 2p12 were found in acute and chronic lymphocytic leukaemias as well a...
متن کاملThe trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody.
High temperature requirement A1 (HtrA1) is a trypsin-fold serine protease implicated in the progression of age-related macular degeneration (AMD). Our interest in an antibody therapy to neutralize HtrA1 faces the complication that the target adopts a trimeric arrangement, with three active sites in close proximity. In the present study, we describe antibody 94, obtained from a human antibody ph...
متن کاملProtoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease
High temperature requirement protein A1 (HtrA1), a secreted serine protease of the HtrA family, is associated with a multitude of human diseases. However, the exact functions of HtrA1 in these diseases remain poorly understood. We seek to unravel the mechanisms of HtrA1 by elucidating its interactions with chemical or biological modulators. To this end, we screened a small molecule library of 5...
متن کاملCerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1.
Cerebral small-vessel disease is a common disorder in elderly populations; however, its molecular basis is not well understood. We recently demonstrated that mutations in the high-temperature requirement A (HTRA) serine peptidase 1 (HTRA1) gene cause a hereditary cerebral small-vessel disease, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)....
متن کاملNo association of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 or complement factor H polymorphisms with early age-related maculopathy in a Chinese cohort
PURPOSE Single nucleotide polymorphisms (SNPs) of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 (ARMS2/HTRA1) and complement factor H (CFH) have been reported to be associated with age-related macular degeneration (AMD). The purpose of this study was to investigate the association of ARMS2/HTRA1 and CFH SNPs with early age-related maculopathy (ARM) in a Han Chinese co...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/46048